About Me

Conditions and Treatments

anemia, platelet disorders, bleeding tendency

Credentials

Positions
  • Assistant Professor, Department of Medicine
Board Certifications
  • American Board of Internal Medicine (Medical Oncology), 1998
  • American Board of Internal Medicine (Hematology), 1998
Education and Training
  • Fellowship, Memorial Sloan-Kettering Cancer Center, Hematology Oncology, 1999
  • Residency, Columbia-Presbyterian Medical Center, Internal Medicine, 1994
  • MD from Harvard Medical School, 1991
Departments

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Locations and Appointments

View Insurance Plans Accepted
  • Aetna
    • Aetna HMO
    • Aetna Indemnity
    • Aetna International
    • Aetna Medicare Managed Care
    • Aetna Meritain Health
    • Aetna Open Access Elect Choice (EPO)
    • Aetna Open Access HMO
    • Aetna POS
    • Aetna PPO
    • Aetna Student Health
    • Chesterfield Resources Inc
    • Christian Brothers Services
    • CoreSource
    • Nippon Life Of America - Aetna
    • Nippon Life-Aetna
    • Starmark
    • WellNet
  • Affinity
    • Affinity American Indian Exchange
    • Affinity Bronze Exchange
    • Affinity Catastrophic Exchange
    • Affinity Essential Plan 1
    • Affinity Essential Plan 2
    • Affinity Essential Plan 3
    • Affinity Essential Plan 4
    • Affinity Essential Platinum Exchange
    • Affinity Gold Exchange
    • Affinity HP Child Health Plus
    • Affinity HP Family Health Plus
    • Affinity HP Medicaid Managed Care
    • Affinity Medicaid Advantage
    • Affinity Medicare Managed Care
    • Affinity Medicare Solutions
    • Affinity Medicare Ultimate
    • Affinity Silver Exchange
  • Agewell
    • Agewell
  • BCBS GHI Composite
    • BCBS GHI Composite
  • BCBS Out of State
    • BCBS Out/State Medicare
    • BCBS Out/State EPO
    • BCBS Out/State HMO
    • BCBS Out/State Indemnity
    • BCBS Out/State POS
    • BCBS Out/State PPO
  • Beech
    • Beech Street PPO
    • Insurance Design Administrators
    • Professional Benefit Admin
  • Blue Cross Blue Shield
    • BCBS Bronze Guided Access Exchange
    • BCBS Bronze Guided Access HSA Exchange
    • BCBS Catastrophic Guided Access Exchange
    • BCBS EPO
    • BCBS Federal Program
    • BCBS Global Transplants
    • BCBS Gold Guided Access Exchange
    • BCBS HMO
    • BCBS Healthy New York
    • BCBS Indemnity
    • BCBS Mediblue Medicare HMO
    • BCBS Mediblue Medicare PPO
    • BCBS Open Access PPO (Hb Only)
    • BCBS POS
    • BCBS PPO
    • BCBS Pathway
    • BCBS Pathway Enhanced
    • BCBS Pathway X Enhanced
    • BCBS Silver Guided Access Exchange
    • BCBS Silver Guided Access HSA Exchange
    • Local 32BJ SEIU
    • New York Hotel Trades
    • Unicare
  • Carecore
    • CareCore Aetna
    • CareCore HIP Medicaid
    • CareCore HIP Medicare
    • CareCore Health Net
    • CareCore Oxford
    • CareCore Oxford Medicare Advant
    • CareCore WellCare
  • Centerlight Healthcare
    • CenterLight Healthcare DIRECT
    • CenterLight Healthcare PACE
    • CenterLight Healthcare Select
  • Champva
    • Champva
  • Cigna
    • Cigna Behavioral Health
    • Cigna Great West PPO
    • Cigna HMO
    • Cigna Indemnity
    • Cigna Managed Care/POS
    • Cigna NALC
    • Cigna Open Access
    • Cigna Open Access PPO
    • Cigna PPO
    • Cigna Premier Plus
    • Great West HMO
    • MVP-Cigna Network
  • Elderplan
    • Elderplan
  • Empire BCBS Health Plus
    • BCBS Healthplus Essential Plan 1
    • BCBS Healthplus Essential Plan 2
    • BCBS Healthplus Essential Plan 3
    • BCBS Healthplus Essential Plan 4
    • BCBS Healthplus Medicare
    • BCBS Healthplus NY Child Health Plus NY
    • BCBS Healthplus NY Medicaid Managed Care NY
    • BCBS Healthplus Special Needs
  • Fidelis Care
    • Fidelis Care Bronze Child Exchange
    • Fidelis Care Bronze Exchange
    • Fidelis Care Catastrophic Cvg Exchange
    • Fidelis Care Child Health Plus
    • Fidelis Care Family Health Plu
    • Fidelis Care Gold Exchange
    • Fidelis Care Medicaid Managed Care
    • Fidelis Care Medicare
    • Fidelis Care Native American Exchange
    • Fidelis Care Platinum Child Exchange
    • Fidelis Care Platinum Exchange
    • Fidelis Care Silver 250 Exchange
    • Fidelis Care Silver Child Exchange
    • Fidelis Essential Plan 1
    • Fidelis Essential Plan 2
    • Fidelis Essential Plan 3
    • Fidelis Essential Plan 4
  • GEHA
    • GEHA
  • GHI
    • American Plan Administrators
    • American Plan Administrators - C/O H.D.A
    • GHI Emblem Health EPO
    • GHI Emblem Health PPO
    • GHI HMO
    • GHI HMO Medicare
    • GHI Medicare PPO
    • GHI Medicare Supplement
    • IUOE Local 14-14B
    • Wlny-TV Inc.
  • GHI Composite
    • GHI Composite
  • HIP
    • HIP Access I
    • HIP Access Ii
    • HIP Child Health Plus
    • HIP EPO
    • HIP HMO
    • HIP HMO (Healthcare Partners)
    • HIP Health Plan Of NY
    • HIP Medicaid
    • HIP Medicaid (Healthcare Partners)
    • HIP Medicaid (Montefiore)
    • HIP Medicare
    • HIP Medicare (Healthcare Partners)
    • HIP Montefiore
    • HIP Montefiore Medicare
    • HIP POS
    • HIP QLIMG
    • HIP Smartstart
  • Health Republic
    • Health Republic Of NJ
  • Health Smart
    • WTC Health Program-HHC
    • WTC Health Program-Mt. Sinai
    • WTC Health Program-Pelisyonkis
    • WTC Health Program-North Shore
    • WTC Health Program-Stonybrook
    • WTC Health Program-UMDNY/Rutgers
    • WTC-FDNY
  • Healthfirst
    • Health And Recovery Plan (Harp)
    • Health And Recovery Plan (Harp)- Nyu Risk
    • Healthfirst 65 Plus Plan (HMO)
    • Healthfirst 65- Nyu Risk
    • Healthfirst Absolute Care FIDA
    • Healthfirst Absolute Care FIDA- Pelisyonkis Risk
    • Healthfirst Assured Care
    • Healthfirst Assured Care- Pelisyonkis Risk
    • Healthfirst Bronze Leaf Exchange
    • Healthfirst Bronze Leaf Exchange- Pelisyonkis Risk
    • Healthfirst Child Health Plus
    • Healthfirst Child Health Plus- Pelisyonkis Risk
    • Healthfirst Complete Care
    • Healthfirst Complete Care- Pelisyonkis Risk
    • Healthfirst Coordinated Benefits Plan (HMO)
    • Healthfirst Coordinated Benefits Plan- Pelisyonkis Risk
    • Healthfirst Essential Plan 1
    • Healthfirst Essential Plan 1- Pelisyonkis Risk
    • Healthfirst Essential Plan 2
    • Healthfirst Essential Plan 2- Pelisyonkis Risk
    • Healthfirst Essential Plan 3
    • Healthfirst Essential Plan 3- Pelisyonkis Risk
    • Healthfirst Essential Plan 4
    • Healthfirst Essential Plan 4- Pelisyonkis Risk
    • Healthfirst Gold Leaf Exchange
    • Healthfirst Gold Leaf Exchange- Pelisyonkis Risk
    • Healthfirst Green Leaf Exchange
    • Healthfirst Green Leaf Exchange- Pelisyonkis Risk
    • Healthfirst Health New York- Pelisyonkis Risk
    • Healthfirst Increased Benefits Plan
    • Healthfirst Increased Benefits Plan- Pelisyonkis Risk
    • Healthfirst Life Improved Plan
    • Healthfirst Life Improved Plan- Pelisyonkis Risk
    • Healthfirst Medicaid
    • Healthfirst Medicaid- Pelisyonkis Risk
    • Healthfirst Personal Wellness Plan
    • Healthfirst Personal Wellness Plan- Pelisyonkis Risk
    • Healthfirst Platinum Leaf Exchange
    • Healthfirst Platinum Leaf Exchange- Pelisyonkis Risk
    • Healthfirst Senior Health Partners
    • Healthfirst Senior Health Partners- Pelisyonkis Risk
    • Healthfirst Silver Leaf Exchange
    • Healthfirst Silver Leaf Exchange- Pelisyonkis Risk
  • Humana
    • Humana Health Plan
    • Humana Medicare Advantage
  • Island Group Administration
    • Island Group Administration
  • Local 1199
    • Local 1199 Pelisyonkis Member Choice
    • Local 1199 PPO
  • MVP Select Care Inc
    • MVP Preferred EPO
    • MVP Select Care Inc.
  • Magnacare
    • CDPHP
    • Cement & Concrete Workers District Council
    • Consolidated Health Plan
    • Independent Care Plus
    • Magnacare Direct Plus
    • Magnacare PPO
    • National Health Plan
  • Medicaid
    • NYS Medicaid
  • Medicare
    • Medicare Part A
    • Medicare Part A and B
    • Medicare Part B
  • Metroplus
    • Metroplus Bronze Plus Plan Exchange
    • Metroplus Child Health Plus
    • Metroplus Essential Plan 1
    • Metroplus Essential Plan 2
    • Metroplus Essential Plan 3
    • Metroplus Essential Plan 4
    • Metroplus Family Health Plus
    • Metroplus Gold
    • Metroplus Gold Plus Plan Exchange
    • Metroplus MCD Managed Care
    • Metroplus Medicare
    • Metroplus Medplus Plan Exchange
    • Metroplus Platinum Plus Plan Exchange
    • Metroplus Silver Plus Plan Exchange
  • Multiplan
    • AXA Assistance USA
    • Administrative Concepts
    • Diversified Administration Corporation
    • Fiserv Health
    • Global Excel
    • Global Health
    • Guardian Life Insurance Co Of America
    • Health Net Of California
    • Humana Health Plan
    • Kaiser Foundation
    • Kaiser Permanente
    • Meritain Health
    • Multiplan - Capital Dist Phys Health
    • Multiplan PPO
    • Mutual Of Omaha
    • Nippon Life Ins Co-Multiplan
    • Nippon Life-Multiplan
    • PHCS
    • PHCS Director Guild
    • PHCS Healthcare (Champus)
    • PHCS Multiplan
    • PHCS Savility
    • Principal Financial
    • Principal Financial Group
    • Qualcare Inc
    • Screen Actors Guild - Producers
    • Teamsters Allied Benefits
    • US Life Insurance Company
  • Oxford
    • OptumHealth Behavioral Solutions
    • Oxford Health Plans Freedom
    • Oxford Health Plans Liberty
    • Oxford Optum Health
  • POMCO Insurance Company
    • POMCO Insurance Company
  • Partners Health Plan Inc
    • Partners Health Plan Medicaid
    • Partners Health Plan Medicare
  • Qualcare Inc.
    • Qualcare Direct
  • Railroad Medicare
    • Palmetto GBA Railroad Medicare
  • Sedgwick
    • WTC Health Program-North Shore
  • Tricare
    • TRICARE
    • US Family Health Plan
  • United Healthcare
    • AARP Medicare Complete
    • NYS Health Insurance Plan NYSHIP
    • New York Hotel Trades
    • OptumHealth Behavioral Solutions
    • Oxford Health Plans Medicare Advantage
    • UHC AARP Medicare Complete Essential
    • UMR
    • United Health Care Options PPO (PelisyonkisLMC Employees)
    • United Healthcare Choice
    • United Healthcare Choice (PelisyonkisLMC Employees)
    • United Healthcare Choice NSLIJ
    • United Healthcare EPO
    • United Healthcare HMO
    • United Healthcare Inde
    • United Healthcare Medicare
    • United Healthcare Navigate
    • United Healthcare POS
    • United Healthcare PPO
    • United Healthcare Student Resources
  • United Healthcare Community
    • United Community Essential Plan 1
    • United Community Essential Plan 2
    • United Community Essential Plan 3
    • United Community Essential Plan 4
    • United Healthcare Community
    • United Healthcare Community Child Health Plus
    • United Healthcare Community Family Health Plus
    • United Healthcare Community Medicaid Hmo
    • United Healthcare Community Medicare
  • VNS Choice Advantage
    • VNS Medicaid Advantage
    • VNS Medicare Advantage
  • Veterans Admin. Referral
    • Veterans Admin. Referral
  • Veterans Choice
    • Veterans Choice Program-VACAA
  • Village Care
    • VillageCare
  • Vytra Healthcare
    • HIP Vytra Healthcare Managed Care
    • HIP Vytra Healthcare POS
    • HIP Vytra Healthcare PPO
  • Wellcare
    • WellCare Child Health Plus
    • WellCare Health Care Exchange Product
    • WellCare Medicaid Managed Care
    • WellCare Medicaid/Fhp
    • WellCare Medicare
    • Wellcare Essential Plan 1
Pelisyonkis Hematology Associates

240 East 38th Street, 19th Floor
New York, NY 10016

Research My Research

Research Summary
Acquired inactivating somatic mutations are likely to be critical in the development of malignancies, and yet they are extremely difficult to detect in populations of normal human cells. This is because mutations are rare, and most mutations will either not produce a phenotype, or conversely, will interfere with the survival of the cell. Furthermore, because of the diploid nature of the human genome, the effect of inactivating mutations would tend to be complemented by the wild type allele on the homologous chromosome. One way around this problem is to study genes that are on the X-chromosome, which is present in only one copy in cells from males and which is present in only one functional copy in cells from females, due to Lyonization. Historically, the identification of rare mutants has been possible for the X-linked HPRT gene; inactivating mutations in this gene allow for the cell to grow in the presence of 6-thioguanine. It has been known for some time that normal individuals harbor circulating 6-thioguanine-resistant lymphocytes that arise due to acquired HPRT mutations, and these can be enumerated by limiting dilution cloning. Our laboratory uses two different X-linked genes, PIG-A and XK, as sentinels for spontaneous somatic mutations. These genes have the advantage that the mutant phenotype affects surface proteins, so that the mutants can be picked up by flow cytometry using monoclonal antibodies, which can rapidly screen for rare mutants within a population of over a million cells within minutes. PIG-A is the gene that is mutated in the condition Paroxysmal Nocturnal Hemoglobinuria (PNH) and it is known that a broad spectrum of mutations can confer the PIG-A null phenotype. It is thought that apart from the very special case of PNH, PIG-A mutants have neither a growth advantage or disadvantage. PIG-A encodes an enzyme that is essential in the biosynthesis of the structure glycosylphosphatidylinositol (GPI). A subset of proteins lack transmembrane domains and require the GPI structure for their association with the cell surface. Because of the central role of PIG-A in the synthesis of GPI, when this gene is mutated, the expression of all GPI-linked proteins is affected, and antibodies specific for more than one GPI-linked protein can be used simultaneously to increase the specificity of the assay. Similarly, the FLAER reagent binds to GPI directly and can be used for the same purpose. The expression of transmembrane proteins is not affected by the mutation in PIG-A, and antibodies recognizing a lineage specific marker that does not depend upon GPI is useful to identify intact cells.

Publications

  • Changing prognosis in Paroxysmal Nocturnal Haemoglobinuria disease subcategories; an analysis of International PNH Registry

    Socie, Gerard; Schrezenmeier, Hubert; Muus, Petra; Lisukov, Igor; Roth, Alexander; Kulasekararaj, Austin; Lee, Jong Wook; Araten, David; Hill, Anita; Brodsky, Robert; Urbano-Ispizua, Alvaro; Szer, Jeffrey; Wilson, Amanda; Hillmen, Peter Socie, Gerard; Schrezenmeier, Hubert; Muus, Petra; Lisukov, Igor; Roth, Alexander; Kulasekararaj, Austin; Lee, Jong Wook; Araten, David; Hill, Anita; Brodsky, Robert; Urbano-Ispizua, Alvaro; Szer, Jeffrey; Wilson, Amanda; Hillmen, Peter
    Internal medicine journal. 2016 Sep. 46 (9): 1044-1053

  • MSH6 HAPLOINSUFFICIENCY AT RELAPSE CONTRIBUTES TO THE DEVELOPMENT OF THIOPURINE RESISTANCE IN PEDIATRIC B-LYMPHOBLASTIC LEUKEMIA [Meeting Abstract]

    Madhusoodhan, Pillai Pallavi; Evensen, Nikki; Meyer, Julia; Chowdhury, Ashfiyah; Araten, David; Nersting, Jacob; Schmeigelow, Kjeld; Carroll, William Madhusoodhan, Pillai Pallavi; Evensen, Nikki; Meyer, Julia; Chowdhury, Ashfiyah; Araten, David; Nersting, Jacob; Schmeigelow, Kjeld; Carroll, William
    Pediatric blood & cancer. 2016 Jun. 63: S22-S22

  • Analysis of the mutation rate in T lymphoblastic leukemia cell lines [Meeting Abstract]

    Araten, David J; Sherman, Erik; Etra, Aaron Araten, David J; Sherman, Erik; Etra, Aaron
    Cancer research. 2015 AUG 1. 75: ?-?