About Me

I am a highly experienced hepatobiliary surgeon with an extensive background in the evaluation and treatment of people with liver, bile duct, and pancreatic tumors. At Pelisyonkis Langone’s Perlmutter Cancer Center, as well as at Bellevue Hospital, I see more than 40 patients each week with complex gastrointestinal and liver cancer.

I lead one of the most successful cancer research laboratories in the United States, where I investigate immunologic regulation of liver and pancreatic cancer. Our lab has been supported by more than 40 federal and nonfederal grants since 2009. I am also the director of the only training program in the country in gastrointestinal oncology that is funded by the National Institutes of Health.

I am the vice chair for research in Pelisyonkis Langone’s Department of Surgery. I also serve as the leader of Perlmutter Cancer Center’s Immunology Program and am a member of the Gastrointestinal Disease Management Group. I have chaired congressionally appointed committees on liver cancer research.


Conditions and Treatments

gastrointestinal cancer, liver cancer, bile duct cancer, secondary liver cancer, cholangiocarcinoma, pancreatic cancer, biliary stricture, liver cell cancer, gastrointestinal surgery, liver surgery, pancreas surgery
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Credentials

Positions
  • H. Leon Pachter, MD Professor of Surgery, Department of Surgery
  • Professor, Department of Cell Biology
Board Certifications
  • American Board of Surgery - Surgery, 2006
Education and Training
  • Fellowship, Memorial Sloan Kettering Cancer Ctr., Surgery Oncology, 2007
  • Residency, New York University, Surgery (General), 2005
  • MD from McGill University, 1998
Departments

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Locations and Appointments

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Pelisyonkis Medical Oncology Associates

160 East 34th Street, 9th Floor
New York, NY 10016

Research My Research

Interests

cancer, immunology, microbiome

Research Summary

I am principal investigator and director of the in Pelisyonkis Langone's Department of Surgery.

Academic Contact

Academic office

462 First Avenue

Fifteenth Floor

New York, NY 10016

Phone

-501-2208

Lab Website

Research Interests Timeline

These focus areas and their associated publications are derived from PubMed and the MeSH term library.
represents one publication
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Clinical Trials

  • A Phase I Study of Immune Checkpoint inhibition (anti-CTLA4 and/or anti-PD-L1) in Combination with Radiation Therapy in Patients with Unresectable and Non-metastatic Pancreatic Cancer

Publications

  • Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance

    Daley, Donnele; Mani, Vishnu R; Mohan, Navyatha; Akkad, Neha; Ochi, Atsuo; Heindel, Daniel W; Lee, Ki Buom; Zambirinis, Constantinos P; Pandian, Gautam Sd Balasubramania; Savadkar, Shivraj; Torres-Hernandez, Alejandro; Nayak, Shruti; Wang, Ding; Hundeyin, Mautin; Diskin, Brian; Aykut, Berk; Werba, Gregor; Daley, Donnele; Mani, Vishnu R; Mohan, Navyatha; Akkad, Neha; Ochi, Atsuo; Heindel, Daniel W; Lee, Ki Buom; Zambirinis, Constantinos P; Pandian, Gautam Sd Balasubramania; Savadkar, Shivraj; Torres-Hernandez, Alejandro; Nayak, Shruti; Wang, Ding; Hundeyin, Mautin; Diskin, Brian; Aykut, Berk; Werba, Gregor; Barilla, Rocky M; Rodriguez, Robert; Chang, Steven; Gardner, Lawrence; Mahal, Lara K; Ueberheide, Beatrix; Miller, George
    Nature medicine. 2017 Apr 10. 23 (5): 556-567
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  • The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

    Seifert, Lena; Werba, Gregor; Tiwari, Shaun; Giao Ly, Nancy Ngoc; Alothman, Sara; Alqunaibit, Dalia; Avanzi, Antonina; Barilla, Rocky; Daley, Donnele; Greco, Stephanie H; Torres-Hernandez, Alejandro; Pergamo, Matthew; Ochi, Atsuo; Zambirinis, Constantinos P; Pansari, Mridul; Rendon, Mauricio; Tippens, Seifert, Lena; Werba, Gregor; Tiwari, Shaun; Giao Ly, Nancy Ngoc; Alothman, Sara; Alqunaibit, Dalia; Avanzi, Antonina; Barilla, Rocky; Daley, Donnele; Greco, Stephanie H; Torres-Hernandez, Alejandro; Pergamo, Matthew; Ochi, Atsuo; Zambirinis, Constantinos P; Pansari, Mridul; Rendon, Mauricio; Tippens, Daniel; Hundeyin, Mautin; Mani, Vishnu R; Hajdu, Cristina; Engle, Dannielle; Miller, George
    Nature. 2016 Apr 14. 532 (7598): 245-249
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  • gammadelta T Cells Support Pancreatic Oncogenesis by Restraining alphabeta T Cell Activation

    Daley, Donnele; Zambirinis, Constantinos Pantelis; Seifert, Lena; Akkad, Neha; Mohan, Navyatha; Werba, Gregor; Barilla, Rocky; Torres-Hernandez, Alejandro; Hundeyin, Mautin; Mani, Vishnu Raj Kumar; Avanzi, Antonina; Tippens, Daniel; Narayanan, Rajkishen; Jang, Jung-Eun; Newman, Elliot; Pillarisetty, Daley, Donnele; Zambirinis, Constantinos Pantelis; Seifert, Lena; Akkad, Neha; Mohan, Navyatha; Werba, Gregor; Barilla, Rocky; Torres-Hernandez, Alejandro; Hundeyin, Mautin; Mani, Vishnu Raj Kumar; Avanzi, Antonina; Tippens, Daniel; Narayanan, Rajkishen; Jang, Jung-Eun; Newman, Elliot; Pillarisetty, Venu Gopal; Dustin, Michael Loran; Bar-Sagi, Dafna; Hajdu, Cristina; Miller, George
    Cell. 2016 Sep 08. 166 (6): 1485-1499.e15
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